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Mutating Corona Virus


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"R" number for covid infections is now over 1, mainly due to the K4 asnd K5 omicron variants. Hospitalisations are on the rise,

and this is during summer weather ... and with reinfections occuring

 

On the plus side, Moderna variant vaccine(s) are looking promising, including against the K4/5 variants.

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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Covid

 

The new BA.4 and BA.5 Covid variants are beginning to bite, as covid infections jumped 43 per cent after the jubilee weekend. Meanwhile hospitalisations jumped by 43 per cent in a week on Tuesday.

 

Monkeypox

 

National concern over monkeypox continues to grow as 793 cases have been recorded and the UK Health Security Agency have decided to pre-emptively offer vaccines to gay, bisexual and men who have sex with men, who are seen to be at higher risk.

 

Polio

 

A national incident has been declared after poliovirus was detected in wastewater in London.

 

The virus, which can cause paralysis in rare cases, was identified in sewage samples taken from the capital between February and May 2022, according to the UK Health Security Agency.

 

UKHSA said it was “likely” there has been spread of a vaccine-derived poliovirus type 2 (VDPV2) between closely linked people in North-East London, with infected individuals believed to be shedding the virus in their faeces. So far, no suspected cases have been reported or confirmed.

 

- Independent health news letter

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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also TB  is doing the rounds

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R.I.P my beautiful grey ghost, gone but never forgotten, taken so suddenly, 04/07/2004 ~ ~ 02/03/2017

Gone but never forgotten,Little Miss Sunshine, Alisha Marie. 15/12/2005 ~ ~ 13/02/2006

Our  beloved Dalmatian Jazz,  gone to join Wal at Rainbow Bridge, hope you are now pain free .  20/9/2005 ~ ~ 24/3/2019

 

 

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 The polio in sewage ukhsa thinks it a mutation from a live vaccine potentially

WWW.GOV.UK

Investigation underway to protect public, who are urged to ensure polio vaccines are up to date, especially parents of young children who may...

 

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The bailiff: A 12th Century solution re-branded as Enforcement Agents for the 21st Century to seize and sell debtors goods as before Oh so Dickensian!

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WWW.INDEPENDENT.CO.UK

Covid waves are likely to have a ‘deleterious’ impact on hospital waiting times, warns senior medic

 

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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I think that's right, given the way cases are going.

 

I haven't stopped wearing one in medical settings, including the pharmacy and I hope more people will do this.

Illegitimi non carborundum

 

 

 

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Mrs OR dragged me to the 02 for a concert a week last Sunday 
We came away with two things 
Dose of COVID each , just recovering after six days with it despite having more vacations than a pin cushion (god knows what it would have been like without them)
And an empty bank account having paid £7.10
for two Starbucks medium coffees 😀

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People now coming back from holidays abroad with Covid.  This is going to cause major disruptions, as transport operators, businesses etc will not be able to provide services to customers.

 

 

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I don't know enough to comment on what's in this article but Imperial College is a respected institution and has a strong medical side. It's thought provoking.

 

WWW.THEGUARDIAN.COM

‘Living with the virus’ is proving much harder than the early vaccine success suggested, says professor of immunology Danny Altmann

 

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Illegitimi non carborundum

 

 

 

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Perhaps the only way forward is to live with Covid being around and accept the problems it causes., while waiting for better vaccinations to become available.

 

But to protect health services, if there is a lot of Covid in circulation, to recommend LFT's to be taken before visiting elderly or those with health conditions that make them vulnerable.  And to identify the most vulnerable who should be shielded.

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1. I'm not so sure LFTs are at all effective with omicron v.4 and V.5. even when highly symptomatic - and the Omicron variants transmit very quickly with very low 'quantity

Its claimed that perhaps 50% of 'colds' are actually covid. I know a number of people who have had (or have) cold symptoms, often for unusually extended periods, yet they continue to test negative (including myself)

 

2. The point that there isnt any real 'herd immunity' .. at least until a generation or 2 hence and many million more deaths .. Sure I've already stated this here. Although the confirmed science is quite recent, the projected science always made that most likely.

 

3. long Covid ....

 

 

and too true HB, Masks + vaccinations are the most effective resource

Variant vaccines are on the near horizon, but with millions infected - mutations are generating generating generating, and its very unlikely we are even beyond (hopefully approaching) the end of the beginning of this as yet.

 

 

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 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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Posted (edited)

Its likely it will be a variant vaccine for the autumn vaccine project, although its likely to be a vaccine intended targeting BA1, already limited effectiveness (but not ineffective) against v4+5 - and who knows what the variants will be in 3+ months

 

we also have recombinent versions to worry about. Covid really is learning our makeup very effectively.

 

 

Edited by tobyjugg2

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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Posted (edited)

and despite the apparently current very high level of people with extended cold/flu like symptoms (which seems likely peoples immune systems catching colds and catching up after the lockdowns), which are reported as half covid - half colds/other respiratory issues, current projections seem to be for a very bad flu season in line with a real upsurge in covid infections with a high possibility of a raft of new covid variants with unknown infectiousness/harm this Autumn.

Edited by tobyjugg2

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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Worth a careful and considered peruse. There's so much garbage being spouted around this, but there are some golden nuggets of truth.

 

 

GENETICLITERACYPROJECT.ORG

“Could THIS twice-daily probiotic supplement filled with gut friendly bacteria help beat Long Covid?” That’s the headline in the Daily Mail...

 

Dig out the fermented cabbage .. (sauerkraut)

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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On 23/06/2022 at 10:53, brassnecked said:

 The polio in sewage ukhsa thinks it a mutation from a live vaccine potentiallygovuk-opengraph-image-dade2dad5775023b05

 


It IS a mutation from a live (attenuated) vaccine strain (the UKHSA notes make that clear).

What isn’t clear is if the mutation is “reversion to wild type”, where the mutation from the attenuated strain makes it able to again cause the disease polio.

 

Shedding of the live attenuated vaccine virus has always been recognised. It is why the sewage surveillance system was set up (the surveillance that picked up sustained detection of the virus rather than the usual, expected, sporadic detection every now and again of imported vaccine strains)

 

Once the risk of “reversion from wild type” risk from shed vaccine exceeded the risk from polio for the U.K., this was when the U.K. switched back from live-attenuated (“sugar lump” oral) vaccine to the non-live injected vaccine to remove the risk FROM people vaccinated in the U.K. passing on the attenuated virus / it reverting to “wild type”.

 

This vaccine derived strain detected here is from virus that has come into the U.K. with someone vaccinated abroad with the attenuated vaccine, OR a non-vaccinated U.K. traveller returning to the U.K. having met the vaccine strain abroad.
 

 

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17 hours ago, tobyjugg2 said:

1. I'm not so sure LFTs are at all effective with omicron v.4 and V.5. even when highly symptomatic - and the Omicron variants transmit very quickly with very low 'quantity

Its claimed that perhaps 50% of 'colds' are actually covid. I know a number of people who have had (or have) cold symptoms, often for unusually extended periods, yet they continue to test negative (including myself)

 


Where is your evidence? (For the LFD’s in use in the U.K. having low sensitivity, with the “highly symptomatic” for BA.4 and/or BA.5? Folks, don’t hold your breathe for this as that poster rarely if ever can back up their assertions.

 

You do know coronavirus HKU-1 is circulating, too, and likely HCoV-229E, HCoV-OC43, and HCoV-NL63. (I’ve seen 2 lab reports for HKU-1 in hospitalised patients with other health conditions as part of being asked to help with “how do we explain these to people so they know it is different to Covid”)

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Regarding the variant vaccines, there are 2 current approaches:

1. Bivalent vaccines - which are targeted against both the 'original Wuhan' stain and the 'first omicron variant

2. Vaccine specifically targeting the early Omicron variant (not the 4/5 'omicron variants)

 

Note

Neither are specifically targeting the .4 or .5 omicron variants and have reduced effectiveness against them, although all vaccines (with varying levels of effectiveness) do seem to reduce the incidence of severe illness and death, even against the newer variants - so far.

Note 2

Quite a bit (but not all) of the effectiveness against corona-virus variants seems to be during a relatively short period (3-6 months) after the vaccinations - almost certainly due to the different forms of our bodies defenses. (see links below)

 

* Given that Coronavirus is demonstrating it's happy to 'merge with prior strains, option 2 seems a poor option at this stage in the game despite it claiming slightly better effectiveness against the .4/5 variants.

* Coronavirus has already demonstrated will ready re-infect with variants and will recombine with earlier variants

 

Seems clear to ne that a cocktail (like the flu vaccine) still seems to be the best option - as it has from the start.

+ At this stage that the variant vaccines are targeting the 'first Omicron variant (6 months in), without a speedy (sub 3 months) ability to be modified for newer variants is a massive failure.

 

 

Background on defense mechanisms and background on these variants

 

WWW.MSDMANUALS.COM

Defenses Against Infection - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.

 

WWW.IMMUNOLOGY.ORG

Via cytotoxic cells When a virus infects a person (host), it invades the cells of its host in order to survive and replicate. Once inside, the cells of the...

 

 

WWW.NCBI.NLM.NIH.GOV

Just as vertebrates have developed many different defenses against pathogens, so pathogens have evolved elaborate strategies to evade...

 

 

Plus

WWW.PREVENTION.COM

This new variant is set to be the most common one in the U.S. soon.

 

 

WWW.NEWS-MEDICAL.NET

A new study describes mutations found in the SARS-CoV-2 BA.1 variant in Hong Kong and New Zealand.

 

WWW.SCMP.COM

They are now the dominant strains in the US and elsewhere, and many countries are expecting a surge in cases in the coming months.

 

 

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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Here's Stephen Reicher of SAGE on the current situation with masks, etc.

 

WWW.THEGUARDIAN.COM

Acting like the virus is no longer a risk undermines our trust in public health measures, says psychologist Stephen Reicher

 

Illegitimi non carborundum

 

 

 

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Its now hitting mainstream news

 

"They noted that, contrary to a popular held belief that vaccines and previous infection would provide “a wall of immunity”, nations are instead experiencing “wave after wave of new cases”."

 

 

WWW.INDEPENDENT.CO.UK

‘Even having had Omicron, we’re not well protected from further infections,’ said Prof Danny Altmann

 

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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The BA.2.75 sub-variant has some alarming mutations in the key spike protein. It has a saltation

 

of 16 mutations. Eight of them are in the spike region: four in the N-terminal domain and four in the receptor-binding domain (see graphic below).

unnamed.png

 

SCIENCE.THEWIRE.IN

Just as the BA.5 sub-variant was poised to take over all the other omicron sub-variants, BA.2.75 popped up to complicate the Indian SARS-CoV-2...

 

WWW.MEDPAGETODAY.COM

Now spreading in at least 10 countries, but it's too soon to tell how virulent or deadly it is

 

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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Worth reading as its not 'stating the ****** obvious as it first might seem

 

 

One coronavirus infection wards off another

Data from Qatar suggest that natural immunity induced by infection with SARS-CoV-2 provides a strong shield against reinfection by a pre-Omicron variant for 16 months or longer. This protection against catching the virus dwindles over time, but immunity triggered by previous infection also thwarts the development of severe COVID-19 symptoms — and this safeguard shows no signs of waning. Scientists also warn that the study’s results do not mean that infected people can skip vaccination. A separate study by many of the same authors found that people who had both natural immunity and vaccine immunity were substantially more protected against the virus than people who had only one of the two.

Nature | 4 min read &
Reference: medRxiv preprint (not peer reviewed) & The New England Journal of Medicine paper

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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  • 2 weeks later...

Not completely convinced yet, but looks promising

 

WWW.SCIENCEDAILY.COM

Researchers have shown that a specific area of the SARS-CoV-2 spike protein is a promising target for a pan-coronavirus vaccine that could offer...

 

WWW.NEWS-MEDICAL.NET

Researchers in the United States have identified antibody-inducing epitopes of severe acute respiratory syndrome coronavirus 2...

 

WWW.NATURE.COM

Scientific Reports - Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination

 

WWW.NEWS-MEDICAL.NET

A new mouse model suggests that prior HCoV-OC43 S immunity primes neutralising antibody responses to otherwise subimmunogenic...

 

PUBMED.NCBI.NLM.NIH.GOV

In the midst of the unceasing COVID-19 pandemic, the identification of immunogenic epitopes in the SARS-CoV-2 spike (S) glycoprotein plays a...

 

 

PUBMED.NCBI.NLM.NIH.GOV

As COVID-19 cases continue to rise, it is imperative to learn more about antibodies and T-cells produced against the causative virus, SARS-CoV-2...

 

 

 

 "Moral emptiness"  "unrepentant and inveterate liar"  "devoid of decency"

Boris Johnson (Mendex est)

called 'Prince of Lies' 'Unfit'  and 'The Divider'

 

“The failure of the cheerleaders of Brexit to acknowledge the consequences of Brexit as due to Brexit remains remarkable.” - David Schneider

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